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神经再生修复——上海市生物化学与分子生物学学会成立六十周年系列线上报告会第四期

2021-06-18

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报告题目       应激:行为、免疫与精神药理

报告摘要       To benefit from opportunities and cope with stress in the environment, animals must adapt their behavior to avoid danger and to maximize rewards. We are focusing on dissecting the neural circuits underlying stress and reward. Specifically, we found that corticotrophin-releasing hormone (CRH) neurons in paraventricular nucleus (PVN) organize adaptive stress response by complementarily integrating reward and stress signals. Also, we found that PVN and CeA CRH neurons are the command center of brain–spleen pathway in mice, through which behaviour can modulate adaptive immune responses. Together, these knowledges may provide guidance for developing novel treatment strategies for neuropsychiatric diseases, such as depression and anxiety.

  

 

报告题目    a-MSH/MC4R信号调控器官再生

报告摘要      

a-MSH/MC4R通路在调控哺乳动物的能量代谢平衡中起重要作用。目前对MC4R在哺乳动物器官中的表达和功能分析尚缺乏深入研究。在前期研究提示MC4R调控了爪蛙断肢再生的基础上,我们进一步探究了MC4R在小鼠器官再生中的功能。发现a-MSH能够拯救缺失单拷贝Mc4r基因导致的小鼠断趾再生延迟现象;a-MSH能够弥补迷走神经缺失给新生小鼠心脏再生带来的阻碍,恢复因去神经带来的MC4R蛋白表达水平的下调和心功能异常。我们结果提示a-MSH/MC4R对器官再生具有广泛的调节作用,为进一步分析中枢神经系统来源信号及内分泌系统调控器官再生提供了研究基础。